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This methylation profile is previously obtained within the MBL stage3 and remains somewhat steady as time passes. Even so, some CLL have intratumor variability in specific regions, which can alter the expression of several genes and facilitate tumor evolution.71 Of Observe, this variability is bigger in U-CLL than in M-CLL and it is associated with raising number of subclones.seven,seventy one
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This methylation profile is currently obtained within the MBL stage3 and stays rather steady as time passes. Even so, some CLL have intratumor variability in sure locations, which can alter the expression of a number of genes and aid tumor evolution.seventy one Of Observe, this variability is greater in U-CLL than in M-CLL and is affiliated with escalating number of subclones.seven,seventy one
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